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Pharmaceutical Intermediates - Commercial Products

S.No
 NAME OF INTERMEDIATE CAS NUMBER API Application
1
 6-Iodoquinazolin-4(3H)-one  16064-08-7 Lapatinib
2
 4-(3-Chloropropyl)morpholine  7357-67-7 Gefitanib
3
 Methyl-3-hydroxy-4-methoxybenzoate  6702-50-7 Gefitanib
4
 Methyl-5-hydroxy-4-methoxy-2-nitrobenzoate  215659-03-3 Gefitanib
5
 5-hydroxy-4-methoxy-2-nitrobenzoic acid ethyl ester 1146162-38-0 Gefitanib
6
 (S)-2((S)-4-Methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido) pentanamido)-3-phenylpropanoic acid  868540-16-3 Carfilzomib
7
 N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2- pyrimidineamine 152460-10-1 Imatinib
8
 4-(4-Methylpiperzinomethyl)benzoic acid.2HCl 106261-49-8 Imatinib
9
 4-Phenoxybenzoic acid  2215-77-2 Ibrutanib
10
 3-Iodo-4-methylbenzoic acid 82998-57-0 Ponatinib
11
 Methyl-4-amino-2-methoxybenzoate  27492-84-8 Lenvatinib
12
 4-Amino-2-chlorobenzonitrile  20925-27-3 Lenvatinib
13
 4-Phenylthiopyrrolidine-2-carboxylic acid  105107-84-4 Zofinopril
14
 5-Amino-2,4-ditertiarybutylphenol 873055-58-4 Ivacaftor
15
 4-Oxo-1,4-dihydroquinoline-3-carboxylic acid  13721-01-2 Ivacaftor
16
 4-Oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester 52980-28-6 Ivacaftor
17
 5-Bromo-2-chlorobenzoic acid 21739-92-4 Dapagliflozin
18
 4-(5-Bromo-2-chlorobenzyl)phenylethyl ether  461432-23-5 Dapagliflozin
19
 2-Chloro-5-iodobenzoic acid 19094-56-5 Empagliflozin
20
 (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone 915095-86-2 Empagliflozin
21
 (5-Bromo-2-chlorophenyl)(4-fluorophenyl)methanone  915095-85-1 Empagliflozin
22
 4-(5-Bromo-2-chlorobenzyl)phenol 864070-18-8 Empagliflozin
23
 (S)-3-(2-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran 2744280-76-8 Empagliflozin
24
 5-Bromo-2-methylbenzoic acid 79669-49-1 Canagliflozin
25
 5-Iodo-2-methylbenzoic acid 54811-38-0 Canagliflozin
26
 (5-Bromo-4-methoxy-2-methylbenzyl)phenylethyl ether   Luseogliflozin
27
 1-(2-Chloroacetyl)-pyrrolidine-(2S)-carbonitrile 207557-35-5 Vildagliptin
28
 (2S)-1-[2-[(3-hydroxy-1-adamantyl)amino]-acetyl]
-pyrrolidin-2-carbonitrile		 274901-16-5 Vildagliptin
29
 Sodium-5-(methoxycarbonyl)-6-oxo-1,2,3,6-tetrahydropyridin-4-olate 198213-15-9 Aloserton
30
 3-Ethoxy-4-methoxybenzaldehyde   1131-52-8 Apremilast
31
 3-Amino pthalic Acid HCL 5434-20-8 Apremilast
32
 3-Ethoxy-4-methoxy Benzonitrile 60758-86-3 Apremilast
33
 4-Tertiarybutylbenzene sulphonamide 6292-59-7 Bosentan
34
 2-(4-Nitrophenoxyethyl)chloride  3383-72-0 Dofetilide
35
 N-Methyl-4-nitrophenylethylamine.HCl   166943-39-1 Dofetilide
36
 3-(4-Hydroxyphenyl)propionic acid 501-97-3 Esmolol
37
 4-(2,4-Difluorophenyl)-4-oxobutanoic acid 110931-77-6 Posaconazole
38
 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine 74853-08-0 Posaconazole
39
 (2E,4E)-(5-(4-Methoxy-2,3,6-trimethylphenyl)
-3-methylpenta-2,4-dienyl)triphenyl phosphonium bromide		 54757-44-7 Acitretin
40
 E-Butyl-3-methyl-4-oxobut-2-enoate 54145-95-8 Acitretin
41
 3-(3-Phenylsulfamoylphenyl)acrylic acid   412269-00-2 Belinostat
42
 Methyl-4-acetylbenzoate  3609-53-8 Micafunginm / Mycamine
43
 4-Morpholinoaniline  2524-67-6 Reversine
44
 3-Bromo-2-methylbenzoic acid  76006-33-2 Sonidegib
45
 4-Mercaptophenylacetic acid 39361-84-7 Sonidegib
46
 1-(4-Hydroxymethyl)phenylacetic acid 73401-74-8 Netrasudil
47
 1-Amino-2-methylindoline.Hydrochloride 102789-79-7 Indapamide
48
 4-Chloro-3-sulfamoylbenzoyl chloride 70049-77-3 Indapamide
49
 3-(2-Chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine.HCl 69-09-0 Chloropromazine
50
 2-Butyl-3-(3,5-diiodo-4-hydroxybenzoyl)benzofuran 1951-26-4 Amiodarone
51
 6-Bromo-3-hydroxypyrazine-2-carboxamide 259793-88-9 Favipiravir
52
 (1R,4R)-1-Methyl-4-(prop-1-en-2-yl)cyclohex-2-enol 52154-82-2 Cannabidiol
53
 Para-Menthadienol / (1R,4S)-1-Methyl-4-(prop-1-en-2-yl)
cyclohex-2-enol		 22771-44-4 Cannabidiol
54
 3-(4-Chlorophenyl)propionic acid 2019-34-3 Pitolisant
55
 3-(Piperidin-1-yl)propan-1-ol 104-58-5 Biperidene/ Cycrimine
56
 (R)-N-(2-(4-Isopropyl-4,5-dihydroxazol-2-yl)
-6-methylphenyl)methane sulfonamide		 871360-40-6 Eribuline
57
 4-(4-Nitrophenyl)butyric acid 5600-62-4 Chlorambucil
58
 5-(N,N-Dibenzylglycyl)salicylamide 30566-92-8 Labetalol
59
 3-cyano-4-isopropoxybenzoic acid 258273-31-3 Ozanimod
60
 4-bromobenzene sulfonyl chloride 98-58-8 Ozanimod
61
 4-chloro-3-nitro-5-sulfamoylbenzoic acid 22892-96-2 Bumetanide
62
 3-Nitro-4-phenoxy-5-sulfamoylbenzoic acid 28328-53-2 Bumetanide
63
 3-Amino-4-phenoxy-5-sulfamoylbenzoic acid 28328-54-3 Bumetanide
64
 3-(3, 4-Dihydroxyphenyl)propionic acid 1078-61-1 Dihydrocaffeic Acid
65
 1-(3,4-Dimethoxy-2-Nitrobenzyl)-2-methyl-1,2,3,4-Tetrahydro isoquinoline 16472-50-7 Apomorphine
66
 1,2,6,7-Tetrahydro-8H-indenofuran-8-one 196597-78-1 Ramelteon
67
 3-morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)
-5,6-dihydropyridin-2(1H)-one		 545445-44-1 Apixaban
68
 Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate 27143-07-03 Apixaban
69
 Ethyl 3-Amino bennzoate 582-33-2 Tricaine Mesylate
70
 Sodium 4-Phenylbutyrate 1716-12-7 Sodium Phenylbuterate
71
 (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine 300543-56-0 Levocitrazine
72
 Docusate Sodium 577-11-7 Docusate Sodium
73
 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine 39577-43-0 Flupenthixol
74
 3-[10,10-Dimethyl-9(10H)-anthrylidene]
-N,N-dimethylpropylamine hydrochloride		 10563-70-9 Melitracen Dihydrochloride
75
 6-Chloro-1,3-dimethyluracil 6972-27-6 Urapidil
76
 1-[4-(Benzyloxy)phenyl]-2-bromopropan-l-one 35081-45-9 Isoxsuprine
77
 1-Phenoxypropan-2-amine 35205-54-0 Isoxsuprine
78
 1-(4-Benzyloxyphenyl)-2-[1-methyl-2-phenoxyethylamino] propanone HCL 1860-67-9 Isoxsuprine
79
 (1-[4-(1,1-Dimethyl ethyl)phenyl]-4-(4-hydroxypiperidin-1-yl)butan-1-one 97928-18-2 Ebastine
80
 Methyl 2-oxocyclohexanecarboxylate 10472-24-9 Loxoprofen
81
 2-(4-Bromomethyl)Phenylpropionic Acid 111128-12-2 Loxoprofen
82
 2-{4-[(2-Oxocyclopentyl)methyl]phenyl}propanoic acid 68767-14-6 Loxoprofen
83
 2-(3-Methoxyphenethyl)phenol 167145-13-3 Sarpogrelate
84
 1-(Dimethylamino)-3-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]
-2-propanol hydrochloride 		135261-74-4 Sarpogrelate
85
 5-Nitro salicylic acid 96-97-9 Mesalamine
86
 Fenofibric Acid 42017-89-0 Choline Fenofibrate
87
 5-Chloro-2-Nitro Benzoic Acid 2516-95-2  
88
 2-[2-(3-Methoxyphenyl)ethyl]phenol 167145-13-3  
89
 4-Bromo-3-chloro benzaldehyde 120077-69-2  
90
 4-Bromo-3-chlorobenzoic Acid 25118-59-6  
91
 3-Bromo-1-propanol 627-18-9  
92
 2-Bromo-1-Phenyl Propane 2114-39-8  
93
 Methyl 3-piperidin-1-yl-propanoate 23973-93-5  

Pharmaceutical Intermediates - Under Development

S.No.
 NAME OF INTERMEDIATE CAS NUMBER API Application
1
 2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one 224789-21-3 Vardenafil
2
 (R)-2-((4-Nitrophenethyl)amino)-1-phenylethanol Hydrochloride 521284-21-9 Mirabegron
3
 4-Bromo Methyl Benzoate 2417-72-3  
4
 (1R,5S)-3-ethylbicyclo[3.2.0]hept-3-en-6-one 1235479-61-4 Mirogabilin Besylate
5
 3-ethylbicyclo[3.2.0]hept-3-en-6-one 12354-59-0 Mirogabilin Besylate
6
 2-((1R,5S,6S)-6-(Aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid 2166206-19-3 Mirogabilin Besylate
7
 4,5-Dimethoxy-1-cyanobenzocyclobutane 35202-54-1 Ivabradine Hydrochloride
8
 (S)-1-(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)-N-methylmethanamine 866783-12-2 Ivabradine Hydrochloride
9
 (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride 866783-13-3 Ivabradine Hydrochloride
Note : Above products will NOT be supplied to countries in which these could be in conflict with existing patents. The final responsibility lies exclusively with the buyer.

Pharmaceutical Intermediates - Commercial Products

S.No. NAME OF INTERMEDIATE CAS NUMBER API Application
1 6-Iodoquinazolin-4(3H)-one  16064-08-7  LAPATINIB
2 4-(3-Chloropropyl)morpholine  7357-67-7 GEFITINIB
3 Methyl-3-hydroxy-4-methoxybenzoate  6702-50-7
4 Methyl-5-hydroxy-4-methoxy-2-nitrobenzoate  215659-03-3
5 (S)-2((S)-4-Methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)
pentanamido)-3-phenylpropanoic acid 		 868540-16-3 CARFILZOMIB
6 N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2- pyrimidineamine 152460-10-1 IMATINIB
7 4-(4-Methylpiperzinomethyl)benzoic acid.2HCl 106261-49-8
8 4-Phenoxybenzoic acid  2215-77-2 IBRUTINIB
9 3-Iodo-4-methylbenzoic acid 82998-57-0 PONATINIB
10 Methyl-4-amino-2-methoxybenzoate  27492-84-8 LENVATINIB
11 4-Amino-2-chlorobenzonitrile  20925-27-3
12 4-Phenylthiopyrrolidine-2-carboxylic acid  105107-84-4 ZOFENOPRIL
13 5-Amino-2,4-ditertiarybutylphenol 873055-58-4 IVACAFTOR
14 4-Oxo-1,4-dihydroquinoline-3-carboxylic acid  13721-01-2
15 4-Oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester 52980-28-6
16 5-Bromo-2-chlorobenzoic acid 21739-92-4 DAPAGLIFLOZIN
17 4-(5-Bromo-2-chlorobenzyl)phenylethyl ether  461432-23-5
18 2-Chloro-5-iodobenzoic acid 19094-56-5 EMPAGLIFLOZIN
19 (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone 915095-86-2
20 (5-Bromo-2-chlorophenyl)(4-fluorophenyl)methanone  915095-85-1
21 4-(5-Bromo-2-chlorobenzyl)phenol 864070-18-8
22 (S)-3-(2-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran 2744280-76-8
23 5-Bromo-2-methylbenzoic acid 79669-49-1 CANAGLIFLOZIN
24 5-Iodo-2-methylbenzoic acid 54811-38-0
25 (5-Bromo-4-methoxy-2-methylbenzyl)phenylethyl ether   LUSEOGLIFLOZIN
26 1-(2-Chloroacetyl)-pyrrolidine-(2S)-carbonitrile 207557-35-5 VILDAGLIPTIN
27 (2S)-1-[2-[(3-hydroxy-1-adamantyl)amino]-acetyl]-pyrrolidin-2-carbonitrile 274901-16-5
28 Sodium-5-(methoxycarbonyl)-6-oxo-1,2,3,6-tetrahydropyridin-4-olate 198213-15-9 ALOSETRON
29 3-Ethoxy-4-methoxybenzaldehyde   1131-52-8 APREMILAST
30 3-Ethoxy-4-methoxy Benzonitrile 60758-86-3
30 4-Tertiarybutylbenzene sulphonamide 6292-59-7 BOSENTAN
31 2-(4-Nitrophenoxyethyl)chloride  3383-72-0 DOFETILIDE
32 N-Methyl-4-nitrophenylethylamine.HCl   166943-39-1
33 3-(4-Hydroxyphenyl)propionic acid 501-97-3 ESMOLOL
34 4-(2,4-Difluorophenyl)-4-oxobutanoic acid 110931-77-6 POSACONAZOLE
35 (2E,4E)-(5-(4-Methoxy-2,3,6-trimethylphenyl)-3-methylpenta-2,4-dienyl)
triphenyl phosphonium bromide		 54757-44-7 ACITRETIN
36 E-Butyl-3-methyl-4-oxobut-2-enoate 54145-95-8
37 3-(3-Phenylsulfamoylphenyl)acrylic acid   412269-00-2 BELINOSTAT
38 Methyl-4-acetylbenzoate  3609-53-8 MICAFUNGIN / MYCAMINE
39 4-Morpholinoaniline  2524-67-6 REVERSINE
40 3-Bromo-2-methylbenzoic acid  76006-33-2  SONIDEGIB
41 4-Mercaptophenylacetic acid 39361-84-7
42 1-(4-Hydroxymethyl)phenylacetic acid 73401-74-8 NETARSUDIL
43 1-Amino-2-methylindoline.Hydrochloride 102789-79-7 INDAPAMIDE
44 4-Chloro-3-sulfamoylbenzoyl chloride 70049-77-3
45 3-(2-Chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine.HCl 69-09-0 CHLOROPROMAZINE
46 2-Butyl-3-(3,5-diiodo-4-hydroxybenzoyl)benzofuran 1951-26-4 AMIODARONE
47 6-Bromo-3-hydroxypyrazine-2-carboxamide 259793-88-9 FAVIPIRAVIR
48 Para-Menthadienol / (1R,4S)-1-Methyl-4-(prop-1-en-2-yl) cyclohex-2-enol 22771-44-4 CANNABIDIOL
49 3-(4-Chlorophenyl)propionic acid 2019-34-3 PITOLISANT
50 3-(Piperidin-1-yl)propan-1-ol 104-58-5 BIPERIDEN/ CYCRIMINE
51 (R)-N-(2-(4-Isopropyl-4,5-dihydroxazol-2-yl)-6-methylphenyl)
methane sulfonamide		 871360-40-6 ERIBULIN
52 4-(4-Nitrophenyl)butyric acid 5600-62-4 CHLORAMBUCIL
53 5-(N,N-Dibenzylglycyl)salicylamide 30566-92-8 LABETALOL
54 3-cyano-4-isopropoxybenzoic acid 258273-31-3 OZANIMOD
55 4-bromobenzene sulfonyl chloride 98-58-8
56 methyl 3-piperidin-1-ylpropanoate 23973-93-5  
57 4-chloro-3-nitro-5-sulfamoylbenzoic acid 22892-96-2 BUMETANIDE
58 3-(3, 4-Dihydroxyphenyl)propionic acid 1078-61-1  

Pharmaceutical Intermediates - Under Development

S.No. NAME OF INTERMEDIATE CAS NUMBER API Application
1 2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one 224789-21-3 VARDENAFIL
2 3-morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one 545445-44-1 APIXABAN
3 Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate 27143-07-03
4 (R)-2-((4-Nitrophenethyl)amino)-1-phenylethanol Hydrochloride 521284-21-9 MIRABEGRON
5 4-Bromo Methyl Benzoate 2417-72-3  
6 3-Amino pthalic Acid HCL 5434-20-8 APRIMILAST
7 10-Methoxy-5H-dibenzo[b,f]azepine / 10-Methoxy Iminostilbene 4698-11-7 OXCARBAZEPINE/CARBAMAZEPINE

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